PTB Proteins Induce RNA Looping
Lamichhane, Daubner et al., PNAS
Researchers in the US and Switzerland report that polypyrimidine tract-binding proteins induce RNA looping ― a finding they deduced using FRET, NMR spectroscopy, and in vivo splicing data. They show that two PTB RNA recognition motifs can bind two distant pyrimidine tracts, bringing their 5' and 3' ends in close proximity, thus inducing loop formation.
Simulations Plus Says Acquisition Target Has Chosen a Rival Suitor
A Simulations Plus official said that the firm was "in competition with another suitor, and although the offers were essentially equal, the company we wanted to acquire decided to pursue the other offer."
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