Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Sage Bionetworks Lands $6.7M Grant to Become NCI Center for Cancer Systems Biology
The Sage grant is the first CCSB award that has been disclosed. According to a request for applications for the program issued last year, NCI plans to commit a total of approximately $22.5 million per year to fund up to nine centers for up to five years.
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