Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Q&A: AstraZeneca's Anastasia Christianson Explains How She Stays in Lockstep with Clinical and Research Data
Anastasia Christianson, AstraZeneca's senior director and global discipline lead for biomedical informatics, discusses how she has moved beyond managing data to integrating data.
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