Chromosome-Scale Selective Sweeps and Genomic Diversity in C. elegans
Andersen, Gerke et al., Nature Genetics
Researchers at Princeton University and elsewhere discuss the effects of chromosome-scale selective sweeps on genomic diversity in Caenorhabditis elegans. Taking a high-throughput selective sequencing approach on a collection of 200 wild C. elegans strains, the team found that the nematode's "genome variation is dominated by a set of commonly shared haplotypes on four of its six chromosomes, each spanning many megabases." Further, the team reports on its population genetic modeling experiments, which showed that "this pattern was generated by chromosome-scale selective sweeps that have reduced variation worldwide; at least one of these sweeps probably occurred in the last few hundred years," it writes.
As Pathway Informatics Matures, Users Refine Buying Criteria, and Vendors Adapt
Over the past two years, the commercial market for pathway data and analysis tools has emerged from relative obscurity to take center stage in the life science informatics sector. Even as traditional genomics-based software vendors see their revenues decline, companies like GeneGo, Jubilant Biosys, and Ingenuity Systems are signing deal after deal...Subscribers: click headline for more
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