Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
New Broad Institute Algorithm, Satsuma, Aligns without Seeding, is Fast, and Parallel
The most mature software package in the new tool set is Satsuma, a high-sensitivity, genome-wide synteny program that runs on a massively parallel server farm and is 100 times faster than exhaustive search, according to the Broad developers.
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