Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
The Dilemma: Updating Human Reference Genome without Disrupting Research
The Genome Reference Consortium is "grappling with two communities" when it comes to updating the human reference genome: researchers who need a stable coordinate system for whole-genome analysis and those who are seeking precise and comprehensive information about specific loci.
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