Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Microsoft Research Preps for Summer Launch of Open Source Bioinformatics Toolkit
The Microsoft Biology Foundation includes parsers for common bioinformatics file formats; various algorithms for manipulating DNA, RNA, and protein sequences; and a set of connectors to key bioinformatics web services such as the National Center for Biotechnology Information's Blast.
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