Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Informatics Reaps $92M in NIH Stimulus Grants; Support Centers, Sequence Analysis Garner Most Funds
Awards for bioinformatics support centers and resources garnered the most FY 2009 ARRA funding, with $16.2 million spread across 13 grants. Sequence analysis projects netted the most grants, at 23, and the second-most amount of total funding, with $12.9 million.
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