Hamner, Entelos to Co-develop Drug-Induced Liver Injury Simulation Software

March 13, 2009

By Vivien Marx

The goal of the project is to build a dynamic model of liver function in rats and humans that will account for effects of genetic variations and other variables, such as patient gender, age, behavioral traits, and environmental factors.

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Young Investigator Profile

Erin Carlson

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Papers of Note

Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
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Genetic Data for Modern Genetic Breeds 'Have Yet to Shed Light on Dog Origins'
Larson, Karlsson et al., PNAS
A team led by researchers at the University of Durham investigate the value of modern genetic data to elucidate the origins of dog domestication by analyzing 49,024 autosomal SNPs in 19 wolves and 1,375 dogs, representing 35 breeds. The team reports having uncovered conflicting evidence when correlating the earliest archeological dogs with the geographic locations of 14 breeds thought to be ancient. "These genetically distinct ancient breeds only appear so because of their relative isolation, suggesting that studies of modern breeds have yet to shed light on dog origins," the authors write.
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A study published in Science Translational Medicine suggests high-throughput sequencing is effective for finding post-treatment leukemia cells that can lead to patient relapse. Researchers used sequencing to test matched pre- and post-chemotherapy samples from 43 individuals with T-lineage acute lymphoblastic leukemia. They found that the sequencing method tracked down minimal residual disease in 25 of the cases tested, including several missed by flow cytometry.
Business
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Genome Technology Magazine
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Hamner, Entelos to Co-develop Drug-Induced Liver Injury Simulation Software

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