Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
DIY: Clinical Annotation of Quake Genome Results in New Curated Database of Human Variation
The relational database, which is three times the size of the Human Gene Mutation Database, is housed at Stanford. While there is currently no external web-based access to the database, the researchers are "strongly considering opening access to other researchers, depending on their research intentions."
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