Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
Commercial Informatics Sector Shakeout Continues in 2003; Public Sector Strong
December 22, 2003
The shakeout in the commercial bioinformatics market that began in 2002 gathered momentum during the past year, leaving the sector a bit smaller in December than it was in January. BioInform covered 12 consolidation events during 2003 (see box, p. 5) -- an average of one per month, and around three times as many as occurred in any other year since 2000. [BioInform 04-07-03]....Subscribers: click headline for more
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