Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
Bioinformatics Tools ID Pathways Enriched in Gene Expression Studies of Colorectal Cancer Prognosis
April 26, 2011
Researchers used a variety of bioinformatics tools to crunch data from nearly two-dozen gene expression studies of colorectal cancer, identifying pathways that are enriched in past prognostic studies of the disease.
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