Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
Accelrys, Oxford Nanopore Partner on Software Development for Single-molecule NGS Platform
As part of the deal, nanopore-specific data analysis pipelines for Accelrys' Pipeline Pilot will be offered as the preferred and supported software for secondary and higher level data analysis for Oxford's Nanopore sequencing system upon its commercialization.
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