Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
GWDN Stocks Mixed in July; Affy Soars, Myriad Sags
August 03, 2009
Affymetrix's shares increased nearly 50 percent during the month on the strength of its Q2 results, while Myriad and Celera each dropped more than 20 percent as they said their respective quarterly revenues would be lower than previously expected.
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