Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
GWAS Data Translating Into Improved Drug Safety, Researchers Say
February 22, 2010
At a session at the American Association for the Advancement of Science, GSK genetics head Lon Cardon argued that one of the most immediate practical applications of genome-wide association studies is in decreasing adverse drug events and improving drug safety.
Full-text access for registered users only.
Existing users login here.
New to GenomeWeb? Register quickly here for free access.
New to GenomeWeb? Register quickly here for free access.
Related Stories
- International Team Publishes Large Neuroticism GWAS
July 23, 2010 / GenomeWeb Daily News - UCB, Imperial College Team Up to Identify Epilepsy Gene Regulators
May 21, 2012 / GenomeWeb Daily News - GSK to Buy Cellzome for $99M as Pharma Interest in Chemical Proteomics Continues to Build
May 18, 2012 / ProteoMonitor - With Celgene Partnership Epizyme Hopes to Accelerate Personalized Epigenetic Drug Development
May 16, 2012 / Pharmacogenomics Reporter - Integrated Analysis Defines Potentially Predictive Schizophrenia Risk Genes
May 15, 2012 / GenomeWeb Daily News