Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
Genotyping Study Finds MS Risk Variant More Common in Women
January 06, 2011
By genotyping the major histocompatibility complex gene HLA-DRB1 in individuals from more than 1,000 MS-affected families, researchers have identified sex-specific differences in inheritance patterns for an MS-associated version of the gene.
Full-text access for registered users only.
Existing users login here.
New to GenomeWeb? Register quickly here for free access.
New to GenomeWeb? Register quickly here for free access.
Related Stories
- Large Multiple Sclerosis GWAS Points to Cell-Mediated Immunity Genes
August 10, 2011 / GenomeWeb Daily News - Illumina and University of Oxford to Sequence 500 Human Genomes to Inform Diagnosis, Treatment
August 3, 2011 / Clinical Sequencing News - UK Government Funding Development of Sequencing-Based Cancer Tests
June 21, 2011 / Clinical Sequencing News - NGS-Based Peptide Display Platform Enables Proteome-Wide Screening for Autoantigens
May 27, 2011 / ProteoMonitor - Scienion to Supply Protagen with Microarray Batches for Clinical Validation of Protein Biomarkers
April 22, 2011 / ProteoMonitor