This online seminar will provide an overview of recent research published in the journal Immunity
that demonstrates progress in the standardization of assays for personalized immune response monitoring.
Matthew Albert, co-director and founder of the Center for Human Immunology at Institut Pasteur, will share findings from the Milieu Interieur Project, a population-based study that aims to identify the genetic and environmental determinants of immune phenotype variance and establish a path towards personalized medicine.
Dr. Albert and colleagues have developed a suite of whole blood, syringe-based assay systems that can be used to reproducibly assess induced innate or adaptive immune responses. By eliminating pre-analytical errors associated with immune monitoring, he and his team have defined the protein signatures induced by: (i) medically relevant bacteria, fungi and viruses; (ii) agonists specific for defined host sensors; (iii) clinically employed cytokines; and (iv) activators of T cell immunity.
Initial results provide healthy donor reference values for induced cytokines and chemokines and indicate that the failure to release interleukin 1 alpha is a common immunological phenotype. Dr. Albert will discuss how observed naturally occurring variation of the immune response may help to explain differential susceptibility to disease or response to therapeutic intervention.
The results of this work indicate that the implementation of a general solution for point-of-care assessment of functional immune responses will support harmonization of clinical studies and data sharing.
Participants will learn about the following from this webinar:
• Standardization of whole blood immune assays
• Use of Luminex assays to assess stimulation-induced protein signatures
Director of the Department of Immunology; Co-Director and Founder of the Center for Human Immunology at Institut Pasteur; Adjunct Faculty at Cochin Hospital
Dr. Matthew Albert is an INSERM director of research and full professor working at Institut Pasteur, where he heads a mixed INSERM/Pasteur unit. He received his MD at Cornell University Medical College and his PhD in immunology at Rockefeller University. He trained in Clinical Pathology at New York Presbyterian Hospital and was a Clinical Scholar at Rockefeller University Hospital.
Dr. Albert’s laboratory is centered around a "bedside‐to‐bench" approach to translational research. This has helped him to stay firmly rooted in clinically relevant scientific questions, which has furthered the understanding of disease pathogenesis and helped to establish the proper scientific foundation for the identification of new therapeutic interventions.
He is currently co-coordinating, with Dr. Lluis Quintana-Murci, the Milieu Interieur Consortium, which aims to define the genetic and environmental determinants of immune phenotype variance.