Researchers from the NIH and Pacific Biosciences used long-read, PacBio single-molecule real-time sequencing to profile antibiotic resistance enzyme-containing plasmids present in gram-negative Enterobacteriaceae isolates collected at an NIH hospital during and after a 2011 outbreak of antibiotic resistant Enterobacteriaceae. This approach allowed them to look at both bacterial genome sequences and sequences from plasmids carried by the cell, and enabled the team to identify potential transmission events involving specific plasmids and microbial species.
Australian molecular diagnostics firm Genetic Technologies is undertaking a restructuring aimed at ramping up its US molecular diagnostic operations and commercializing the new version of its BrevaGen breast cancer risk test. Its board has approved the sale and/or divestment of the company's non-core assets, and the firm has finalized commitments for a A$2.15 million (US$1.94 million) financing to support its US MDx plans. The firm plans to soon launch BrevaGenplus test, which would have use for African-American and Hispanic women, as well as Caucasian women.
The National Institute on Aging plans to award up to $800,000 next year to investigators' efforts to develop and plan research projects that will examine epigenetic factors involved in age-related diseases, addressing important questions in the emerging field of geroscience. The researchers will plan and design research projects that will investigate epigenetic risk factors for age-related diseases and conditions, or will undertake small-scale pilot projects focused on the same goals. NIA expects that these projects will receive more funding when they are fully developed.