Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Will 2009 Be Remembered as the Year Personalized Medicine Went Mainstream?
A number of events and trends that arose last year, including the increasing prevalence of direct-to-consumer genomics firms and PGx programs initiated by pharmacy services providers, might just make 2009 the year personalized medicine really started to take hold in the public's mind.
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