Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
TCGA's Ovarian Cancer Study Points to Range of PGx Strategies, Potential Role for PARP Inhibitors
June 29, 2011
The TCGA team identified 68 genes that could be targeted by existing drugs or experimental compounds, and singled out PARP inhibitors as a drug class with particular potential. The study also provides a potential basis for subtype-based diagnostics to stratify patients according to their cancer's genomic variation.
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