Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
Study Suggests Validity of Personal Genetic-Risk Data May Be Inflated
February 11, 2009
In a paper published in the recent PLoS Genetics, researchers suggest that while a “strong association” between certain genes and diseases may be “very valuable for establishing etiological hypotheses,” it may not be useful for gauging an individual’s risk for diseases.
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