Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
Study Suggests Malaria Parasites Accompanied Humans Out-of-Africa
June 18, 2010
Based on genetic data on more than 500 Plasmodium falciparum isolates from around the world, an international research group has concluded that the malaria parasite likely migrated with humans from Africa around 60,000 to 80,000 years ago
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