Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Sequenom Discloses Mishandling of Test Data; Shares Plummet
Sequenom's shares took a beating on Thursday after the firm disclosed that four employees are suspected of mishandling R&D data on its Down syndrome test. The firm said that it would delay the launch of the test until later in the year.
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