Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
Scripps Wins $3.2M NIH Grant to Study Drosophila Genes Linked to Learning, Memory
October 12, 2010
Using genome-wide RNAi transgene libraries of Drosophila genes, researchers at The Scripps Research Institute expect to screen more than 90 percent of the genome for genetic functions involved in acquisition, short-term memory stability, long-term memory, and retrieval.
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