Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Results from Gene ID Studies Could Lead to New Dxs for Genomic Health
Studies presented at ASCO’s annual meeting could lead to the development of two new diagnostics tests, expanding the indication of Genomic Health’s Oncotype DX technology into gauging treatment benefit with Erbitux in colorectal cancer and Taxotere in breast cancer.
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