Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
Qiagen Says Expanded PCR IP Portfolio Will Boost Hardware and Consumables Sales, Drive Entry into IVD Market
New IP agreements with Roche and Idaho Technology not only allow the firm to sell its Rotor-Gene Q thermal cycler and reagents for both research and diagnostic applications, but also extend to high-resolution melting curve analysis technology — a key component in the company's strategy for increasing its foothold in the PCR market. The company's acquisition of DxS has also helped expand its PCR offerings for molecular diagnostics.
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