Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Q&A: Vanderbilt's Roden Discusses Use of EMRs to Find Gene Variants Linked to Drug Response
Vanderbilt University's Dan Roden is leading a project to identify clinically validated gene variants linked to drug response and generate a list of such important variants that will aid healthcare providers recognize pharmacogenomics opportunities in the care of their patients.
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