Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
Pfizer Will Market Monogram Biosciences CCR5 Test to Help Identify Responders to New HIV Drug
May 10, 2006
Monogram s phenotypic CCR5 assay has the opportunity to become the first such test on the market, with the potential to be useful in predicting patient response to other drugs of the same class. Subscribers: click headline for more
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