Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Perlegen Defunct: PGx Firm Shutters Doors After R&D Disappointments, Mounting Losses
A review of the privately held pharmacogenomics company's activities from when it opened its doors in 2000 to just before it shuttered in late 2009 suggests that despite partnerships with academia and big pharma, opportunistic R&D investments in key markets, and at least one recently launched commercial diagnostic product, the company was unable to remain solvent. R&D disappointments, losses related to a government contract, and the economic crisis may have directly forced the company to close.
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