PTB Proteins Induce RNA Looping
Lamichhane, Daubner et al., PNAS
Researchers in the US and Switzerland report that polypyrimidine tract-binding proteins induce RNA looping ― a finding they deduced using FRET, NMR spectroscopy, and in vivo splicing data. They show that two PTB RNA recognition motifs can bind two distant pyrimidine tracts, bringing their 5' and 3' ends in close proximity, thus inducing loop formation.
Navigenics, 23andMe Respond To DTC Genetics Opinion Paper
In an open letter appearing on the companies' web sites, Navigenics and 23andMe addressed criticisms leveled at direct-to-consumer test results in an opinion paper in Nature last month.
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