Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
FDA Chief Commits to Completing Rx/Dx Codevelopment Guidance This Year, Improving Regulatory Science
At a luncheon hosted by the Personalized Medicine Coalition last week, FDA Commissioner Margaret Hamburg said the agency will release its drug/diagnostic codevelopment guidance this year, and discussed how personalized medicine can be advanced through a new NIH/FDA partnership.
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