Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
EMBL: 'Well Prepared' to Address 'Big' Science Despite Loss Due to Dip in EC Funding
In its annual report, the European Molecular Biology Laboratory said it is "well prepared" to tackle challenges posed by the growth of 'big' science as it begins planning its research and operations strategy for the five years starting in 2012.
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