Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
CYP2D6 Genotype and SSRIs Alter Tamoxifen Metabolism
January 06, 2005
The common breast cancer drug tamoxifen may be less effective in women carrying particular alleles of CYP450 genes, as well as in women taking selective serotonin reuptake inhibitors, according to research published in the Jan. 5 issue of the Journal of the National Cancer Institute.... Subscribers: click headline for more
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