Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Cepheid Shares Rise Following NEJM Study on TB Test
According to the study, Cepheid's Xpert MTB/RIF test successfully identified around 98 percent of all cultured-confirmed TB cases, including more than 90 percent of those with smear-negative disease, and had a nearly 98 percent success rate in detecting patients with resistance to the anti-TB drug rifampin.
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