Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
In Australian BRCA Patent Challenge, Plaintiffs Not Satisfied With Myriad's IP Gift
November 03, 2010
Plaintiffs challenging one of Myriad's BRCA patents in the Australian federal court have applied to extend the scope of the case to include additional BRCA patents held by the company.
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