ASCO Reviewer Advises Genotyping to Improve Success for MEK-Inhibiting Cancer Drugs

June 09, 2010

"Seeing that we have had other agents in this class, there should be some sort of selection of tumor types, or some type of genomic profiling, or at least retainment of archival tissue, so that we can go on to profile these patients at a later date," said Patricia LoRusso of Karmanos Cancer Institute at Wayne State University, who reviewed early dosing trials of three MEK inhibitors being developed by GlaxoSmithKline, Merck Serono, and Eisai.

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Papers of Note

Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
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Larson, Karlsson et al., PNAS
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Genome Technology Magazine
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ASCO Reviewer Advises Genotyping to Improve Success for MEK-Inhibiting Cancer Drugs

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