Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
AMA Calls for Directive Restricting Use of DTC Genetic Testing, Expanding MDs’ Role
August 20, 2008
The American Medical Association in June recommended that all genetic testing be carried out under the supervision of a qualified healthcare professional, and said it plans to work with other groups to develop guidelines for advertising DTC genetic tests, and educate physicians about counseling patients their patients about the tests.
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