Family-Based Whole-Genome Sequencing Reveals Candidates for Mendelian Disease
Roach, Glusman et al., Science
Researchers at the Institute for Systems Biology and Complete Genomics have identified candidate disease-causing genes for Miller syndrome and ciliary dyskinesia, both Mendelian disorders. They sequenced the genomes of a family of four, allowing them to determine recombination sites with precision (at 99.999 percent accuracy) and identify rare single-nucleotide polymorphisms. "Our results demonstrate the unique value of complete genome sequencing in families," the authors write.
Affymetrix Transfers Ownership of CLIA Lab to Navigenics
Affy has decided to refocus its efforts on its core microarray platform and being an enabler for the broad adoption of microarrays across all genetic analysis markets, including CLIA lab services. Meanwhile, Navigenics takes over ownership of the lab as the volume of orders for its genetic screening service has increased.
New to GenomeWeb? Register quickly here for free access.