Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
With $190K in ARRA Funding, 23andMe to Validate Web-based Platform to Spur PGx Collaborations
December 22, 2010
The company aims to show that its web-based, customer-reported data-gathering model yields results comparable to traditional research methods — both in terms of the accuracy of phenotypic data reported by customers, as well as the overall ability of the approach to replicate known associations between genes and drug response.
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