Family-Based Whole-Genome Sequencing Reveals Candidates for Mendelian Disease
Roach, Glusman et al., Science
Researchers at the Institute for Systems Biology and Complete Genomics have identified candidate disease-causing genes for Miller syndrome and ciliary dyskinesia, both Mendelian disorders. They sequenced the genomes of a family of four, allowing them to determine recombination sites with precision (at 99.999 percent accuracy) and identify rare single-nucleotide polymorphisms. "Our results demonstrate the unique value of complete genome sequencing in families," the authors write.
Community-Bred GO Terms Aimed to Help Scientists Manage Microbe-Host Interactions
The Plant-Associated Microbe Gene Ontology Consortium presented a vocabulary resource comprising more than 700 words focusing on microbe-host interactions. The words appear as part of eight papers is a special supplement to BMC Microbiology.
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