Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Collaboration and Sustainability are Front and Center as caBIG Celebrates Fifth Anniversary
At the annual caBIG meeting, a number of presenters reported challenges in getting end-users to take advantage of the caBIG resources available to them, while others discussed the difficulty in creating caBIG-enabled resources that are sustainable.
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