Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
UK Group Gets $2M to Develop 3D Assay; Platform Closely Mimics In Vivo Events
February 29, 2008
If cells are cultured three-dimensionally and adopt the same shape that they have in the body, then researchers are more likely to generate data that depicts as accurately as possible what would happen in vivo.
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