Chromosome Painting, Gene Mapping of Tasmanian Devil Facial Tumor Disease
Deakin, Bender et al., PLoS Genetics
A team led by investigators at the Australian National University reports its use of "chromosome painting and gene mapping to deconstruct the DFTD [Tasmanian devil facial tumor disease] karyotype and determine the chromosome and gene rearrangements involved in carcinogenesis." Through its analysis, the team produced detailed maps of both the devil and tumor karyotypes, which the researchers say will aid future genomic investigations into the transmissible cancer.
Sanger’s AVEXIS Maps Large-Scale Cell-Surface Protein Interactions
Cell surface proteins contain insoluble, hydrophobic transmembrane regions, and their extracellular interactions are often very transient, with half-lives of less than a second. According to the researchers, the AVEXIS ELISA-based assay can detect these short-lived interactions with a low false-positive rate, and possibly have uses in drug discovery.
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