Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
NTP Hosts RFI Meeting to Develop ‘Rigorous, Comprehensive’ HTS Toxicity-Screen Battery
September 12, 2008
The National Toxicology Program, seeking information on how to identify and select critical cell-tox pathways to be interrogated by cell-based high-throughput screens, also solicited recommendations on particularly informative molecular targets within these pathways for both cell-based and biochemical assays.
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