Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
Life Tech Wins $870K CIRM Grant To Develop hESC Model of ALS
December 19, 2008
Life Technologies, the company formed from the merger of Invitrogen and Applied Biosystems, said its goal is to create a proof-of-principle model to better understand the pathogenesis of ALS in human tissues by using homologous recombination to establish in vitro disease models in hESCs.
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