Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
Fox Chase Team Uses Murine Cell Assay to Find Novel Kinase Inhibitor
April 25, 2008
The researchers evaluated the ability of IPA-3 to inhibit PDGF-stimulated Pak activation in mouse embryonic fibroblasts. They found that both basal and PDGF-stimulated Pak activity was inhibited by 30 µM of IPA-3, as assessed by an in-gel kinase assay.
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