Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Cellumen to Use CellCiphr Platform To Profile 50 Compounds for NCTR
The NCTR will incorporate the resulting data into its liver toxicity knowledge base, and Cellumen will use the profiling and compound safety data generated to further develop the diversity in its CellCiphr database and cell panels, and to develop its classifier informatics tools.
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