Human Genetic Variation Alters Anthrax Toxin Sensitivity
Martchenko, Candille et al., PNAS
Researchers at Stanford University School of Medicine show that genetic variation affecting capillary morphogenesis gene 2, or CMG2, dramatically alters toxin sensitivity in humans. In its analysis, the team reports on "a CMG2 single-nucleotide polymorphism occurring frequently in African and European populations [that they found] independently altered toxin uptake." The group goes on to suggest "testing of genomically characterized human cell populations may offer a broadly useful strategy for elucidating effects of genetic variation on infectious disease susceptibility."
Cellumen Launches First Cardiotox Panel, Plans to Debut Human Panel in 2009
The new panel is a rat cardiomyocte cell-based panel, based on the H9c2 cell line, and is designed to simultaneously measure eight distinct toxicity indicators in candidate compounds including mitochondrial function, oxidative stress, apoptosis, and cellular hypertrophy.
New to GenomeWeb? Register quickly here for free access.