Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
Caliper Sees Q4 Revenues Decline 9 Percent; Takes $45.3M Charge to Earnings
March 13, 2009
The Hopkinton, Mass.-based firm brought in revenues of $36.7 million for the three-month period ended Dec. 31, down from revenues of $40.3 million for the fourth quarter of 2007. Caliper said that the organic decline in revenues was 2 percent when excluding the effects of product-line divestitures and foreign currency translation.
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