Connection Between Epigenome, Selective Mutability, Evolution, and Human Disease
Li, Harris et al., PLoS Genetics
Researchers at the Baylor College of Medicine and elsewhere propose a "connection between the epigenome, selective mutability, evolution, and human disease" based on the findings of their study on associations of structural mutability with germline DNA methylation and with non-allelic homologous recombination mediated by low-copy repeats. "Combined evidence from four human sperm methylome maps, human genome evolution, structural polymorphisms in the human population, and previous genomic and disease studies consistently points to a strong association of germline hypomethylation and genomic instability," the Baylor-led team writes.
In Brief This Week: Febit; Millipore, Eden Biodesign; Clinical Reference Laboratory, DNA Genotek; Phenomenex; Aushon BioSystems, Institute for Molecular Medicine Finland.
March 26, 2010
In Brief This Week is a Friday column containing news items that our readers may have missed during the week.
Full-text access for registered users only.
Existing users login here.
New to GenomeWeb? Register quickly here for free access.
New to GenomeWeb? Register quickly here for free access.